Role of genetics and lifestyle in dysmenorrhea: Systematic Review

Ángel Alfonso Aguirre Durán; Natalia Martínez Arias; Celia Diez de Los Ríos de la Serna; Mev  Dominguez Valentin

doi:10.54502/msuceva.v3n1a3

Autores/as

Ángel Alfonso Aguirre Durán Faculty of Health Sciences. Unidad Central del Valle del Cauca, Colombia.
Natalia Martínez Arias Faculty of Health Sciences. Unidad Central del Valle del Cauca, Colombia.
Celia Diez de Los Ríos de la Serna University of Barcelona, Spain.
Mev Dominguez Valentin Cancer Research Institute at Oslo University Hospital, Norway.

DOI:

https://doi.org/10.54502/msuceva.v3n1a3

Palabras clave:

Diet, habits, lifestyle, primary dysmenorrhea, secondary dysmenorrhea, susceptibility, genes

Resumen

The aim of this systematic review was to identify the current state of knowledge on the association between susceptibility genes associated with this disorder and the lifestyle of patients (including diet, habits and stress levels). It also highlighted the advances made in this field of study, from a constructive point of view, and pointed out the perspectives for research into this disorder. Dysmenorrhoea, as a primary and secondary disorder, is one of the main causes of partial or total disability in the life cycle of women, both in reproductive age and later. It is recognised as a painful and disabling disorder which, depending on the cultural context, may or may not be cured by medical care, physiotherapy and the use of pain-relieving drugs, from an unknown aetiology (primary dysmenorrhoea) or concomitantly to surgical intervention (secondary dysmenorrhoea). Lifestyle, habits and diet have been identified as related to the intensity of pain and the disability it causes (active or passive use of cigarettes, consumption of alcohol, etc.), and genes related to the interpretation of pain generated by the patient from the morphology of the hypothalamus and the associative function of pain (BNDF Val66Met polymorphism) have been identified, as well as alterations in cytokines (in primary dysmenorrhoea), prostaglandins and an influence of the Cyp1A1 gene (in passive smokers). The study perspective is usually non-integrative and limited to the site studied, as well as to professional, laboratory, imaging (gynaecological and genetic) and/or molecular resources, which can only in a few cases be of an integral approach. Limitations are compounded by the fact that not all the populations studied are usually educated about menstruation, which also limits compatibility and comparability among studies.

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Biografía del autor/a

Ángel Alfonso Aguirre Durán, Faculty of Health Sciences. Unidad Central del Valle del Cauca, Colombia.

Dr. Aguirre obtained his PhD in Biomedical Sciences-Microbiology, research line Molecular Biology at the University of São Paulo (Brazil) Dr. Aguirre has supervised the teaching of microbiology in the Biological Sciences and Obstetrics programmes at the University of São Paulo, Brazil and has teaching experience in microbiology at the Universidad del Valle, Colombia and the Pontificia Universidad Javeriana-Cali, Colombia. He is currently Professor of Cellular and Molecular Biology in the Medicine and Nursing programmes at the Unidad Central del Valle del Cauca, Colombia.

Natalia Martínez Arias, Faculty of Health Sciences. Unidad Central del Valle del Cauca, Colombia.

Professional nurse with clinical experience in adult intensive care, administrative experience as auditor of medical accounts in third level clinic and programme coordinator in first level hospital, teaching experience in the Central Unit of Valle del Cauca, Colombia, where she teaches the subjects of General and Specific Nursing Care and Nursing Process. She has research experience in directing and judging undergraduate theses in the areas of quality of care, mental health, application of epistemological models in nursing, nursing process, among others.

Celia Diez de Los Ríos de la Serna, University of Barcelona, Spain.

A nurse with over 15 years’ experience in oncology and a Masters in Research, she is currently studying for her PhD at the University of Barcelona, Spain. She has worked in Spain and England as a specialist nurse in oncology and genetic counselling and has completed a postgraduate course in advanced practice in Southampton. She has also worked as an advanced practice nurse and completed courses in genetic counselling and cancer genetics. She currently works as a researcher for a European organisation (European Oncology Nursing Society) and as a nurse in clinical practice. She is co-chair of the EONS Education Group and is part of international research groups related to oncology nursing and genetics.

Mev Dominguez Valentin, Cancer Research Institute at Oslo University Hospital, Norway.

Dr. Mev Domínguez is a leading Peruvian scientist currently working on hereditary and familial neoplasia at the Cancer Research Institute at Oslo University Hospital in Norway. She graduated from the Faculty of Biology at the Universidad Nacional Mayor de San Marcos (UNMSM) and has studied at prestigious universities in Brazil. Dr. Mev Domínguez holds a doctorate in oncology from the Hospital A.C. Camargo in Brazil. She also completed post-doctoral studies at Lund University in Sweden and the Jean Perrin Centre in France. He is currently part of the hereditary and familial neoplasia group at the Institute of Cancer Research, Oslo University Hospital, Norway.

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